Adicobal® contains Mecobalamin and is a kind of endogenous coenzyme B12:

As a coenzyme of methionine synthetase, mecobalamin plays an important role in transmethylation in the synthesis of methionine from homocysteine.

• Mecobalamin is well transported to nerve cell organelles, and promotes nucleic acid and protein synthesis: Еxperiments in rats show that mecobalamin is better transported to nerve cell organelles than cyancobalamin and promotes nucleic acid and protein synthesis more than cobamamide does. Experiments with cells from the brain origin and spinal nerve cells in rats also show mecobalamin to be involved in the synthesis of thymidine from deoxyuridine, promotion of deposited folic acid utilization and metabolism of nucleic acid.

• Mecobalamin promotes axonal transport and axonal regeneration. In rat models with streptozotocin-induced diabetes mellitus, mecobalamin normalizes axonal skeletal protein transport in sciatic nerve cells. Mecobalamin exhibits neuropathologically and electrophysiologically inhibitory effects on nerve degeneration in neuropathies induced by drugs, such as adriamycin, acrylamide, and vincristine (in rats and rabbits), models of axonal degeneration in mice and neuropathies in rats with spontaneous diabetes mellitus.

• Mecobalamin promotes myelination (phospholipid synthesis): Mecobalamin promotes the synthesis of lecithin which is the main constituent of medullary sheath lipid. It also increases myelination of neurons in rat tissue culture more than cobamamide does.

• Mecobalamin restores delayed synaptic transmission and diminished neurotransmitters back to normal: Mecobalamin restores end-plate potential induction early by increasing nerve fiber excitability in the crushed sciatic nerve in rats. In addition, mecobalamin normalizes diminished levels of acetylcholine in brain tissue of rats fed with a choline-deficient diet.

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

Adult Dosage

The usual adult dosage for oral use is 3 tablets (1,500 μg of mecobalamin) daily divided into three doses. The dosage may be adjusted depending on the patient’s age and symptoms.